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Inside a analyze in breast cancer cells, the combination of lapatinib, a twin HER2/neu and EGFR tyrosine kinase inhibitor, with INK128 prevented both HER2 and HER3 phosphorylation induced by INK128 and developed synergistic induction of cell Dying in numerous HER2-beneficial cell strains resistant to trastuzumab and lapatinib. In vivo3-O-p-Coumaroy